牛与猪中枢替换的长期结果:一个多中心分析
M Broadwin1, N Ramkumar2, D J Malenka3
1Department of Surgery, Lehigh Valley Health Network, 1200 South Ceder Crest Blvd, PA 18103, Allentown, USA.
Cardiology research and practice
|July 10, 2023
概括
这项研究发现,在牛和猪中米特拉置换之间,长期存活或重新手术风险没有显著差异. 这些发现对于接受 mitra 门手术的患者至关重要.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 临床结果研究研究
背景情况:
- 国家指导方针越来越多地建议在严重的二次腹中进行心肌置换 (MVR).
- 这导致了对额头骨生物假体的更多使用,但对假体类型的比较结果的数据有限.
- 了解基于生物假体材料的长期临床结果对于手术决策至关重要.
研究的目的:
- 为了比较接受牛肉与猪肉美肌活体假体的患者之间的长期生存和重新手术风险.
- 分析两种生物假体类型之间的外科手术期间并发症和住院病率的差异.
主要方法:
- 在2001-2017年间,对1284名接受MVR或MVR+冠状动脉旁路移植 (CABG) 的患者进行了回顾性分析.
- 倾向性得分匹配 (1:1) 用于平衡牛 (n=801) 和猪 (n=483) 群体之间的基线并发症,最终得到了432对匹配的对.
- 主要终点是全因死亡率;次要终点包括住院发病率,30天死亡率,住院时间和重新手术风险.
主要成果:
- 在整体队列中,猪接收者患糖尿病,COPD和冠状动脉疾病的比率更高.
- 在倾向分数匹配后,在牛和猪门之间,长期存活率 (HR 0.97;P=0.756) 或重新操作的风险 (HR 0.54;P=0.225) 没有显著差异.
- 在匹配组之间没有观察到术后并发症,住院发病率或30天死亡率的差异.
结论:
- 这项多中心研究表明,在倾向性得分匹配后,在牛和猪生物假体中关节置换之间,在长期生存或重新操作风险方面没有显著差异.
- 在匹配的队列中,两种假肢类型之间的外科并发症和住院结果也相似.
- 这些发现表明,假肢材料 (牛与猪) 可能不是中枢置换中长期结果的重要决定因素.
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