单拍3D光声学计算机断层扫描,配有密集的阵列,用于跨功能成像
Rui Cao1, Yilin Luo1,2, Jinhua Xu1,2
1Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
ArXiv
|July 10, 2023
概括
这项研究引入了一种先进的光声学计算机断层扫描 (PACT) 系统,用于实时,无标签的功能性脑成像. 新的PACT系统克服了头骨的局限性,改善了人类的跨头骨成像.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 神经科学是一个神经科学.
背景情况:
- 光声学计算机断层扫描 (PACT) 为功能性大脑研究提供无标签的血液动力学成像.
- 跨骨PACT受限于声学扭曲和光线穿透骨的不足.
研究的目的:
- 设计一种能够克服跨脑成像挑战的新型PACT系统.
- 为了实现高分辨率,实时3D功能性脑成像 in vivo.
主要方法:
- 开发了一个带有3072通道半球超声波传感器阵列 (1MHz中心频率) 的PACT系统.
- 采用750nm和1064nm激光器进行深度光透和横成像.
- 演示了20 Hz的单次3D成像和通过ex vivo人类头骨的成像.
主要成果:
- 在高SNR的母乳组织中达到~9厘米的单射光透深度.
- 通过ex vivo人类头骨成功进行了跨的PACT成像.
- 在组织幽灵和人类受试者中展示了单次3D PACT成像.
结论:
- 设计的PACT系统有效地克服了跨膜成像障碍.
- 这项技术对人类实时,体内功能神经成像具有重大潜力.
相关概念视频
Imaging Studies III: Computed Tomography
28
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
28
Computed Tomography
4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
Positron Emission Tomography
4.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K


