快速评估晶核和生长动力学:种子和未种子实验的比较
Andrew Cashmore1,2, Russell Miller1,2, Hikaru Jolliffe2
1Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow G1 1XJ, U.K.
Crystal growth & design
|July 10, 2023
概括
这项研究提出了一种快速的实验方法来测量晶体核和生长动力学. 该工作流准确量化了阿尔法-甘氨酸的初级和二级核和生长速度,有助于过程优化.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
- 结晶科学 结晶科学
背景情况:
- 了解结晶动力学对于控制晶体大小分布和纯度至关重要.
- 精确测量核和生长率对于过程设计和优化至关重要.
- 现有的方法通常依赖于适应人口平衡模型,这可能会引入假设和不准确性.
研究的目的:
- 开发和验证一个实验工作流来快速评估初级和二级核和晶体生长动力学.
- 在不同的超和下,量化水溶液中的α-甘氨酸的核和生长动力学.
- 提供一种方法来估计绝对运动速率,而不依赖于模型适配.
主要方法:
- 利用小规模的激动瓶体实验与现场成像用于晶体计数和大小.
- 进行种子和未种子实验,以评估不同超和水平的结晶动力学.
- 分析了初级核,二级核和晶体生长之间的相互依赖.
主要成果:
- 作为超和的函数,成功量化了alpha-glycine的核和生长动力学.
- 证明了种子实验的必要性,以在低超和下缓慢的初级核形成.
- 获得了初级和二级核和增长率的绝对值,没有模型拟合假设.
结论:
- 开发的工作流允许快速准确地评估结晶动力学.
- 核和生长率之间的定量关系为合理的过程操纵提供了洞察力.
- 这种方法有助于优化批量和连续结晶过程.
相关概念视频
Crystal Growth: Principles of Crystallization
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Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
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Recrystallization: Solid–Solution Equilibria
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Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
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