针对小儿固体瘤的向免疫激活:补充当地控制方法的机会
Emily P Vonderhaar1,2, Michael B Dwinell1,2,3,4, Brian T Craig2,4
1Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
Frontiers in immunology
|July 10, 2023
概括
儿科固体瘤往往具有远程转移,可以抵抗手术或辐射. 调节外科手术期间的免疫反应可以保持抗瘤免疫力,并改善这些具有挑战性的病例的结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症免疫学 癌症免疫学
- 手术瘤学手术瘤学
背景情况:
- 手术和放射治疗是儿科固体瘤的标准治疗方法.
- 远程转移性疾病往往逃避局部治疗,影响患者的结果.
- 局部疗法可以抑制全身抗瘤免疫力,可能促进瘤生长.
研究的目的:
- 在常见的儿科固体瘤中审查瘤免疫微环境.
- 检查对手术和放射治疗的免疫反应.
- 探索术后免疫的治疗调节,以改善转移性疾病的结果.
主要方法:
- 关于瘤免疫学和外科手术期间免疫反应的文献综述.
- 对外科手术前窗口中免疫激活剂的现有证据的分析.
- 识别翻译研究中的知识缺口.
主要成果:
- 儿童固体瘤的局部控制可以诱导全身免疫抑制.
- 术后免疫调节提供了一个潜在的策略来增强抗瘤免疫力.
- 有证据支持在外科手术期间使用免疫激活剂.
结论:
- 了解瘤免疫学和术后反应对于治疗调节至关重要.
- 针对外科手术期间的免疫力可能会防止局部治疗变得亲瘤性.
- 需要进一步的研究来弥合知识差距,并推进翻译应用.
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