在不同温度下测量和关联瑞在烯基醇和2-醇中的可溶性数据
Homa Rezaei1,2, Elaheh Rahimpour2,3, Fleming Martinez4
1Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Heliyon
|July 10, 2023
概括
在烯糖醇和2-醇混合物中的德费里的溶解度随着温度和烯糖醇度的增加而增加. 数学模型准确地预测了这些可溶性趋势,有助于配方开发.
科学领域:
- 物理化学 物理化学
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 德费里是一种口服铁化剂,对于控制铁过载至关重要.
- 了解其溶解度对于开发有效的口服剂型至关重要.
- 非水性溶剂,如烯基醇和2-醇经常用于药物配方.
研究的目的:
- 为了确定deferiprone的热力学特性和可溶性.
- 为了研究deferiprone在二醇-2-醇混合物中的溶解行为.
- 评估用于预测deferiprone溶解性的数学模型.
主要方法:
- 在各种温度和溶剂组合下实验测量deferiprone的溶解度.
- 使用四种数学模型的可溶性数据的相关性.
- 使用范特霍夫和吉布斯方程进行热力学分析.
主要成果:
- 德费里的溶解度与温度和二醇质量分数正相关.
- 数学模型与实验数据有很好的一致性 (平均相对偏差<3.6%).
- 热力学分析提供了关于溶解过程的见解.
结论:
- 烯基醇-2-醇混合物是适合使用德费里的溶剂.
- 开发的模型可以可靠地预测deferiprone的溶解度.
- 这项研究有助于合理设计deferiprone口服配方.
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