对过敏性鼻炎患者尿液差异蛋白的分析
Na Liu1,2,3, Jitu Wang1,2,3, Xueyan Wang4
1Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Heliyon
|July 10, 2023
概括
尿蛋白学揭示了过敏性鼻炎 (AR) 患者的明显蛋白质变化,为早期诊断提供了潜力. 这些发现突出了确定AR评估生物标志物的新途径.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍的过敏性疾病.
- 早期诊断和干预对于管理AR至关重要.
- 研究尿蛋白质学可以帮助AR诊断和评估.
研究的目的:
- 在AR患者的尿液中识别差异表达蛋白 (DEPs).
- 探索尿蛋白质学在AR诊断中的临床实用性.
- 通过蛋白质分析了解AR背后的分子机制.
主要方法:
- 用TMT标记的质谱法用于尿蛋白学.
- 在AR患者和正常对照 (NC) 之间分析了蛋白质.
- 生物信息分析包括基因本体学 (GO),KEGG和蛋白质与蛋白质相互作用 (PPI) 网络.
主要成果:
- DEP与细胞-细胞粘附,补充级联和酶活性有关.
- 像HLA-DRB1,WFDC12和DEFA4这样的上调蛋白与幽默免疫反应有关.
- 下调调节的蛋白质如GUSB,SQSTM1和KIT参与蛋白质域结合.
结论:
- 不同的尿蛋白样本与AR病理生理学有关.
- 尿路蛋白质组学对开发AR的新生物标志物具有前景.
- 对AR的尿蛋白生物标志物的进一步研究是有必要的.
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