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在COVID-19感染的埃及患者中,遗传多态,严重程度和治疗反应之间的关联

Abdelrahman Alaa¹, Neven Sarhan¹, Mohamed Gamal Lotfy El-Ansary²

¹Clinical Pharmacy Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

Frontiers in pharmacology

|July 10, 2023

概括

在ACE-1和ACE-2基因中的单核酸多态 (SNP) 与埃及患者的COVID-19严重程度有关. 这些遗传变异,特别是ACE-1 rs4343和ACE-2 rs908004,可以预测疾病的严重程度和住院时间.

科学领域:

遗传学是一个遗传学.
传染性疾病传染性疾病
分子生物学分子生物学

背景情况:

随着COVID-19的流行,人们需要了解影响疾病严重程度和患者结果的因素.
血管激素转化酶2 (ACE-2) 和跨膜血清蛋白酶2 (TMPRSS2) 蛋白质对于SARS-CoV-2进入宿主细胞至关重要.
ACE-1在调节ACE-2表达中的作用表明它可能对COVID-19的发病和严重程度产生影响.

研究的目的:

研究ACE-1,ACE-2,TMPRSS2基因中的单核酸多态 (SNPs) 与COVID-19严重程度之间的关联.
评估这些基因多态化与埃及患者的治疗反应,住院和ICU入院之间的关系.
为了确定COVID-19疾病进展的潜在遗传预测因素.

主要方法:

一项观察性前性队列研究,涉及109名COVID-19患者和20名健康志愿者.
患者被分为非严重的 (门诊) 和严重的 (住院,ICU) 组.
对ACE-1 rs4343,TMPRSS2 rs12329760和ACE-2 rs908004进行了基因定型.

主要成果:

在严重的COVID-19患者中,ACE-2 rs908004的GG基因型和野生等位基因明显更普遍.
在重症患者组中,ACE-1 rs4343的突变等位基因也显著占主导地位.
在TMPRSS2 rs12329760多态和COVID-19严重程度之间没有发现显著的关联.

结论:

在ACE-1和ACE-2基因中的SNP与埃及人口的COVID-19疾病严重程度有关.
这些遗传标记可以作为预测COVID-19严重程度和住院时间的指标.
需要进一步的研究来探索这些遗传预测因素的临床实用性.

关键词:

在ACE1中,ACE1是ACE1.在ACE2中,ACE2是ACE2.在 COVID-19 疫情中,这就是TMPRSS2的原因.遗传多形态主义是一种遗传多形态主义.严重程度的严重程度.

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