氧化对COVID-19的住院死亡率的影响
Samar Aboulenain1, Nakeya Dewaswala1, Fergie Ramos2
1Department of Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, FL.
HCA healthcare journal of medicine
|July 10, 2023
概括
氧化 (HCQ) 对住院COVID-19患者没有显示好处. 这项研究发现死亡率没有显著差异,但HCQ的使用与急症监护室入院人数增加和住院时间延长有关.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 抗疟疾药物氧化 (HCQ) 已被研究其抗病毒性质.
- 关于其在治疗2019年新冠肺炎疾病 (COVID-19) 中有效性的证据仍然是不确定的和争论的.
研究的目的:
- 为了比较HCQ在住院COVID-19患者的疗效和安全性.
- 评估HCQ对住院死亡率,ICU入院,机械通风和住院时间的影响.
主要方法:
- 追溯队列研究涉及175名住院COVID-19患者.
- 对接受HCQ和不接受HCQ的患者之间的结局进行比较.
- 包括考克斯回归在内的统计分析,以关键临床变量进行调整.
主要成果:
- 在HCQ和对照组之间,在全因住院死亡率上没有统计学上显著的差异 (p=0.72).
- 接受HCQ治疗的患者显示了更高的ICU入院率,机械通风和长时间停留时间.
- 没有观察到QTc延长或心脏骤停率的显著差异.
结论:
- 在住院COVID-19患者中使用氧化 (HCQ) 不会改善死亡率.
- 治疗HCQ与增加的发病率有关,包括更高的ICU入院率和更长的住院时间.
关键词:
在 COVID-19 疫情中,在 QTc 间隔.这就是SARS-CoV-2病毒.队列研究是指队列研究.冠状病毒冠状病毒的新冠病毒.医院死亡率 医院死亡率氧化chloroquine 的使用情况死亡率 死亡率流行病是一种流行病.幸存率 幸存率 生存率治疗药物 治疗药物更多相关视频
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