阿片类药物使用障碍与发作事件之间的关联在酒精使用障碍患者中
Hiroko Furo1,2,3,4, Ankita Podichetty5, Marisa Whitted2
1Department of Psychiatry and Behavioral Sciences, The University of Texas Health at San Antonio, San Antonio, TX, USA.
Substance abuse : research and treatment
|July 10, 2023
概括
患有酒精使用障碍 (AUD) 和阿片类药物使用障碍 (OUD) 的患者与仅有一种疾病的患者相比,发作风险更高. 这项研究强调了双重诊断患者的发病率增加,为风险评估提供了信息.
科学领域:
- 神经科学和临床医学
- 药物成医学和神经病学
背景情况:
- 在酒精使用障碍 (AUD) 和之间,以及在阿片类药物使用障碍 (OUD) 和与戒断有关的之间存在确定的关联.
- 在患有AUD和OUD并发的患者中,发作的风险增加仍然在很大程度上未得到量化.
- 了解双重诊断患者的发病率对于全面的患者护理至关重要.
研究的目的:
- 为了调查和比较患有双重AUD和OUD,仅AUD和仅OUD的患者之间的发病率.
- 为了确定AUD和OUD的双重诊断是否与单一诊断相比增加了发作风险.
- 确定这些患者群体中与发作风险相关的人口因素.
主要方法:
- 从2018年9月至2022年8月的948个医疗保健系统中,利用了来自948个医院住院患者的30777928次非身份化数据.
- 应用国际疾病分类第十版 (ICD-10) 代码用于识别AUD,OUD和发作的遭遇.
- 按人口因素 (性别,年龄,种族) 和主要付款人的分层分析.
主要成果:
- 在AUD和OUD双重诊断的患者 (8.07%) 与仅AUD (7.55%) 相比,发作事件在统计学上更常见.
- 双重诊断患者的发作几率比只有AUD或只有OUD的患者高.
- 人口统计分析揭示了显著的性别差异,并确定白人种族和医疗保险是跨群体最常见的特征.
结论:
- 双重诊断AUD和OUD与具有统计学意义的发作发作的更高发病率有关.
- 来自大型多系统数据库的研究结果为AUD和OUD患者的发作风险提供了关键的见解.
- 这些信息可以帮助针对AUD和OUD患者群体中的高风险人口群体进行准和管理.
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