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尿路感染在当前研究中的定义:系统性审查
Manu P Bilsen1, Rosa M H Jongeneel1, Caroline Schneeberger2
1Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Open forum infectious diseases
|July 10, 2023
概括
尿路感染 (UTI) 的定义在研究中差异很大,缺乏一致的标准. 本次审查强调,迫切需要统一定义,以改善尿路感染的临床研究和患者护理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 临床研究方法论 临床研究方法论
背景情况:
- 由于多种临床和诊断因素,定义尿路感染 (UTI) 是复杂的.
- 对于尿路感染的现有研究定义缺乏标准化,使比较分析复杂化.
- 最近的研究表明,尿路感染的诊断标准存在显著的异质性.
研究的目的:
- 系统地审查和分析当前科学文献中使用的尿路感染的各种定义.
- 在最近的研究中确定尿路感染诊断标准的共同参数和变异.
- 强调需要为研究目的制定一个统一的尿路感染定义.
主要方法:
- 2019年1月至2022年5月期间发表的47项研究的系统审查.
- 研究的重点是治疗或预防性干预,在患有尿路感染的成年患者.
- 分析诊断标准,包括症状,发烧症和尿液培养结果.
主要成果:
- 85%的研究需要症状,28%需要尿液,55%需要尿液培养.
- 只有11%的研究需要所有三个标准来诊断尿路感染.
- 在细菌尿值 (10^3到10^5 CFU/mL) 和急性囊炎和炎炎的定义中观察到显著的变化.
结论:
- 目前对尿路感染的定义在最近的研究中高度异构.
- 缺乏基于共识的标准阻碍了可靠的尿路感染研究和临床实践.
- 对尿路感染的标准化研究参考标准至关重要.
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