在2型糖尿病患者中血清伊斯敏-1增加,但在糖尿病感觉运动外围神经病变中没有增加
Jiaxin Liao1, Yuting Li1, Xiaoting Gui1
1Department of Endocrinology, The Huai'an Hospital Affiliated to Xuzhou Medical University and The Second People's Hospital of Huai'an, Xuzhou Medical University, Huai'an, People's Republic of China.
概括
血清石敏-1 (ISM1) 是2型糖尿病的危险因素. 增加的ISM1与糖尿病女性的肥胖有关,但不是糖尿病神经病变.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物化学 生物化学
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 糖尿病感觉运动外围神经病变 (DSPN) 和肥胖是常见的T2DM并发症.
- 伊斯敏-1 (ISM1) 是一种蛋白质,其在代谢健康中的作用尚不完全理解.
研究的目的:
- 调查血清ISM1水平与T2DM之间的关联.
- 为了检查DSPN患者的血清ISM1变化.
- 为了评估血清ISM1水平与肥胖相关的糖尿病成年人.
主要方法:
- 一项横截面研究包括180名参与者 (120名T2DM,60名对照).
- 使用ELISA测量了ISM1血清度.
- 参与者根据T2DM状态,DSPN存在和BMI (瘦,超重,肥胖) 进行分类.
主要成果:
- 与对照组相比,T2DM患者的血清ISM1水平显著更高 (P <0.001).
- 血清ISM1被确定为T2DM的一个独立风险因素 (OR=4.218,P=0.001).
- 肥胖的糖尿病女性的血清ISM1水平低于瘦身和超重的同行 (P <0.05),男性和整体没有显著差异.
- 在血清ISM1和DSPN之间没有发现显著的相关性.
结论:
- 血清ISM1是T2DM的一个危险因素.
- 血清ISM1与成人糖尿病患者的肥胖症有关,表明性变态.
- 血清ISM1水平与DSPN没有相关性.
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