在初级Sjogren综合征中神经损伤
Naram Khalayli1, Mhd Fares Bouri2, Molham Wahbeh2
1Resident in Internal Medicine.
Annals of medicine and surgery (2012)
|July 10, 2023
概括
神经损伤在初级Sjogren综合征中很常见,一般性症状如头痛和认知问题是普遍存在的. 早期考虑神经系统疾病对于这些患者的有效治疗至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 主要Sjogren综合征 (pSS) 是一种慢性自身免疫性疾病,神经参与的发病率可变,从2.5%到60%不等.
- 了解pSS中神经损伤的患病率和具体模式对于准确的诊断和管理至关重要.
- 关于pSS神经表现的先前研究是有限的,特别是在特定人群中.
研究的目的:
- 评估叙利亚人口样本中神经损伤的患病率和特征,该样本具有原发性Sjogren综合征.
- 确定与pSS相关的常见神经症状和模式.
- 探索神经学发现与特定生物标志物或临床特征之间的潜在相关性.
主要方法:
- 一项涉及大马士革医院48名被诊断患有原发性Sjogren综合征的患者的横截面研究.
- 数据收集包括患者采访,临床检查和实验室/放射学评估 (例如,心动脉多普勒,MRI,唤起潜力).
- 收集的信息主要集中在疾病的持续时间,发病,神经症状和认知功能,使用标准化尺度 (贝克抑郁指数,MMSE).
主要成果:
- 在34名患者 (70.8%) 观察到中枢神经系统的参与.
- 一般神经表现 (85%) 比局部表现 (77.5%) 更常见,头痛和认知障碍是最常见的症状.
- 偏头痛是主要的头痛模式;MRI显示了21名患者的异常,引起的潜能在52%是积极的.
结论:
- 神经损伤在初级Sjogren综合征中非常普遍,经常呈现普遍症状.
- 头痛,认知障碍和疲劳是常见的,这表明神经系统的广泛参与.
- 在各种神经系统疾病的差异诊断中,应考虑初级Sjogren综合征.
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