相关实验视频
Updated: Jul 24, 2025

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
Published on: February 9, 2024
关于CASC11在癌症中的作用的综述
Soudeh Ghafouri-Fard1, Atefeh Harsij2, Bashdar Mahmud Hussen3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
长非编码RNA癌症易感性11 (CASC11) 是一种瘤基因. 升高的CASC11表达与癌症预后不佳相关,并影响瘤的进展,迁移和入侵.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 是生物过程中的新兴调节者.
- 癌症易感性11 (CASC11) 是一个位于8q24.21.21染色体上的lncRNA.
- 在各种人类癌症中观察到异常的CASC11表达.
研究的目的:
- 审查CASC11在癌症发展和进展中的作用.
- 总结目前对CASC11在致癌过程中的分子机制的理解.
- 巩固来自细胞,体内和临床研究的发现.
主要方法:
- 对研究CASC11在癌症中的研究的文献综述.
- 在不同类型的瘤中分析CASC11表达模式.
- 检查CASC11在癌细胞生物学中的功能作用.
- 研究CASC11与其他分子和途径的相互作用.
主要成果:
- 在多种癌症类型中,CASC11的表达上调.
- 高CASC11表达与不良的瘤预后有关.
- CASC11促进癌细胞的增殖,迁移和入侵.
- CASC11调节了自和亡等生物过程.
- CASC11与miRNA,蛋白质和转录因子相互作用.
- CASC11调节关键信号通路,包括Wnt/β-catenin和EMT.
结论:
- 在人类癌症中,CASC11作为瘤原性 lncRNA 起作用.
- CASC11代表了一个潜在的诊断和治疗目标.
- 需要进一步的研究来充分阐明CASC11的致癌作用.
更多相关视频
12:14CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
Published on: June 2, 2022
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
相关概念视频
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Abnormal Proliferation
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...