在患有甲状腺功能增强症的猫和患有超大变性心肌病的猫身上进行心脏宏观和显微镜比较研究
Izabela Janus1, Agnieszka Noszczyk-Nowak2, Joanna Bubak1
1Department of Pathology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
The veterinary quarterly
|July 10, 2023
概括
猫类甲状腺功能增强症会导致严重的心肌结构变化,不像过度缩性心肌病,影响所有腹腔壁. 这些心脏变化发生在高甲状腺猫的正常壁厚的情况下.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 内分泌学 在内分泌学.
- 病理学 病理学 病理学
背景情况:
- 甲状腺功能障碍是老猫的常见内分泌病,影响心脏功能.
- 之前的研究发现甲状腺功能过高的猫患有心脏异常,但缺少心肌血管结构和与高伤心肌病症的比较.
- 治疗过甲状腺功能高的猫的详细病理数据以前没有发表.
研究的目的:
- 为了评估猫类甲状腺功能障碍症中的心脏病理变化.
- 为了比较这些变化与猫类高性心肌病变的变化.
- 为了研究甲状腺功能高的猫的心肌血管变化.
主要方法:
- 病理学和组织病理学检查40只猫类心脏.
- 这些组包括:甲状腺功能增强症 (17),多变性心肌病症 (13),和对照组 (10).
- 室腔壁,血管和心肌整体结构的比较分析.
主要成果:
- 甲状腺功能过高的猫没有出现心室壁缩,与缩性心肌病变的病例不同.
- 基因组学变化在甲状腺功能增强症和缩性心肌病症中同样发达.
- 甲状腺功能高的猫在所有心室壁上表现出更突出的血管变化和变化,而不仅仅是左心室.
结论:
- 猫类甲状腺功能障碍导致严重的心肌结构变化,尽管心脏壁厚度正常.
- 甲状腺功能障碍的组织学损伤很普遍,影响所有心室壁.
- 血管变化是猫类甲状腺功能障碍症中心脏病理的一个显著特征.
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