贝内斯科TM对反流症症状的临床影响:双盲随机选的安慰剂受控试验
Thijs Kuipers1,2, Renske A B Oude Nijhuis1,2, Jeroen M Schuitenmaker1,2
1Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers Location University of Amsterdam, Amsterdam, the Netherlands.
Neurogastroenterology and motility
|July 10, 2023
概括
这项研究发现,与安慰剂相比,基于Quercetin的补充剂benescoTM在患有胃食道逆流病 (GERD) 的个体中没有显著改善反流症状. 需要进一步的研究来探索其他GERD管理选项.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种常见的胃肠道疾病.
- 标准的GERD治疗包括生活方式的改变和质子抑制剂 (PPI).
- 一些患者寻求天然替代疗法来缓解GERD症状.
研究的目的:
- 为了评估benescoTM的疗效,一个基于氨酸的营养补充剂,在缓解GERD症状.
- 评估benescoTM对食道屏障功能和反流症状严重性的影响.
主要方法:
- 进行了一项双盲,随机,安慰剂对照试验.
- 患有反流症状的参与者接受了本尼斯科TM (200毫克奎尔塞丁) 或安慰剂的药片,每天三次,持续六周.
- 主要结局是治疗成功,定义为反流性疾病问卷得分减少≥50%.
主要成果:
- 在benescoTM组中,39%的患者获得治疗成功,而安慰剂组的47% (p=0.468) 获得成功.
- 两组之间没有发现无反流症天 (10对10,p=0.673) 或无反流症夜 (38对39,p=0.409) 的显著差异.
- 与GERD相关的生活质量和参与者报告的成功也没有显著的群体差异.
结论:
- 贝内斯科TM在减少GERD症状方面与安慰剂相比没有显著的益处.
- 这些发现表明,基于素的补充剂,如benescoTM中所述,可能不是有效的独立治疗GERD.
- 需要进一步研究奎尔素的作用及其在GERD管理中的最佳作用.
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