基于Zwitterionic纳米囊的伤口包裹具有多种药物的渐变释放功能的功能,用于有效的伤口愈合
Jiahui Zhou1, Kaishun Xia2, Yuting Li1
1Zhejiang Key Laboratory of Plastic Modification and Processing Technology, College of Materials Science& Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. duguangyan@zjut.edu.cn.
Journal of materials chemistry. B
|July 10, 2023
概括
这项研究介绍了一种新型的伤口包裹,使用热敏的zwitterionic纳米囊来控制,特定阶段释放抗炎和再生药物,显著提高伤口愈合效率.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药物输送系统 药物输送系统
背景情况:
- 皮肤损伤很普遍,需要有效的伤口愈合策略.
- 开发具有连续释放能力的多种药物伤口包仍然是一个重大挑战.
- 目前的包裹往往缺乏精确的控制药物释放动力学不同的愈合阶段.
研究的目的:
- 设计一种多种药物加载的伤口带,具有受监管的,多途径的药物释放系统.
- 为了实现抗炎和组织再生剂的特定阶段释放.
- 为了验证开发的伤口剂在促进有效的伤口愈合方面的有效性.
主要方法:
- 在双层织物之间制造一个结合热响应性zwi-terionic纳米囊 (ZNs) 的伤口带.
- 在ZNs中,对织物表面和人类基本纤维细胞生长因子 (bFGF,再生) 施加诺夫洛克萨 (抗炎药).
- 描述ZN特性 (盐反应抑制,过渡温度接近37°C) 和药物释放动力学.
- 与对照带相比, * in vivo * 伤口愈合性能的评估.
主要成果:
- 伤口带显示盐反应被抑制,过渡温度约为37°C.
- *实验室*释放显示了快速的诺弗洛素释放 (~24小时) 和持续的bFGF释放 (~168小时),与炎症和增殖阶段保持一致.
- 在体内的实验证实了渐变释放带的优越伤口愈合效率.
结论:
- 开发的基于zwitterionic纳米囊的伤口包裹有效地实现了多种药物的分离梯度释放.
- 这种策略成功地将药物释放特征与特定的伤口愈合阶段相匹配,从而提高愈合结果.
- 这种方法为设计基于先进的zwitterionic纳米囊生物医学应用提供了新的见解.
相关概念视频
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...