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在人工肺膜上使用基胆/肝素复合涂层,以提高血红相容性

Donghai Sheng¹, Lin Zhang¹, Hao Jia¹

¹State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.

Langmuir : the ACS journal of surfaces and colloids

|July 10, 2023

概括

研究人员使用带有抗凝固涂层的聚4-甲基-1-) 空心纤维膜 (PMP HFMs) 开发了新的人工肺膜. 这些增强的膜显示出更好的气体透性和血液相容性,在动物研究中预防血栓形成长达21天.

科学领域:

生物材料科学生物材料科学
医疗设备工程医疗设备工程
聚合物化学聚合物化学

背景情况:

在体外膜氧化 (ECMO) 中的人造肺膜面临着气体透性差,血泄漏和血液凝结等挑战.
这些问题损害了设备功能和患者安全.

研究的目的:

开发用于聚4-甲基-1-) 空腔纤维膜 (PMP HFMs) 的新型抗凝涂层,以提高人工肺的血液兼容性和气体透性.
为了评估这些修改膜的性能和安全性.

主要方法:

使用热诱导相分离 (TIPS) 制造PMP HFMs.
通过氧化还原方法对PMP HFMs进行表面氧化.
接种肝素 (Hep) 和2 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 三甲基氨基乙烯酸 (MPC) 来制造复合抗凝涂料.
使用气体透,扫描电子显微镜和体外循环实验进行表征.

主要成果:

准备好的PMP HFMs具有双连续的孔结构和密集的表面层,确保了良好的气体透性 (0.8mL/bar·cm2·min氧气透率) 和稳定的气体选择性.
复合型Hep-MPC涂层显示出优异的血液兼容性,在21天内预防了子全血循环测试中的血栓形成.

结论:

开发的带有 Hep-MPC 涂层的 PMP HFM 为人工肺应用提供了一个有前途的解决方案.
生物活性肝素和生物传递性MPC的组合提供了有效的抗凝剂,并保持了基本的膜功能,提高了ECMO患者的安全性.

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