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在帕金森病模型中对线粒体形态学的组织学检查

Dalila Ciceri1, Lierni Gregorio-Zabala1, Xabier Llama-Pino1

  • 1Achucarro Basque Center for Neuroscience.

Journal of visualized experiments : JoVE
|July 10, 2023
PubMed
概括

在帕金森病中观察到线粒体碎片化.

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...