在美国成年人中,暴露与非酒精性脂肪肝疾病之间的关联
1Department of Gastroenterology, Jinhua Hospital of Zhejiang University, Zhejiang, China.
Acta gastro-enterologica Belgica
|July 10, 2023
概括
环境暴露,以尿路水平 (UBLs) 衡量,与非酒精性脂肪肝疾病 (NAFLD) 的风险增加有关. 这种关联在男性中更强烈,突出了潜在的性别特异性健康影响.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
背景情况:
- 关于环境暴露和非酒精性脂肪性肝病 (NAFLD) 的研究有限.
- 巴是一种环境污染物,具有潜在的健康影响.
研究的目的:
- 调查尿路含量 (UBLs) 与成人NAFLD风险之间的相关性.
- 探索该协会中潜在的性别差异.
主要方法:
- 利用了来自国家健康和营养调查的4,556名20岁以上成年人的数据.
- 使用美国脂肪肝指数 (USFLI) 定义的NAFLD≥30.
- 采用多变量逻辑回归来分析UBL和NAFLD风险之间的关联.
主要成果:
- 在自然日志转换的UBL (Ln-UBL) 和NAFLD风险 (OR:1.24) 之间发现了正相关性.
- 与最低四分之一相比,Ln-UBL最高四分之一的人患NAFLD的可能性增加了1.65倍.
- 在男性中,Ln-UBLs和NAFLD之间的关联显著更强 (相互作用的P = 0.003).
结论:
- 尿中的度与NAFLD的患病率有关.
- 这种关联取决于性别,在男性中更为明显.
- 需要进一步的前性研究来证实这些发现.
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