患有阻塞性睡眠呼吸暂停的年轻和中年中国成年人过度白天嗜睡:对认知功能障碍的影响
Sijie Cai1,2, Zhiqiang Li1, Jing Wang1
1Department of Respiratory and Critical Care Medicine, Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Sleep & breathing = Schlaf & Atmung
|July 10, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的过度白天嗜睡 (EDS) 与认知问题有关,特别是记忆回忆. 解决嗜睡可能会改善OSA个体的认知功能.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,OSA) 是一种普遍的疾病,其特征在于在睡眠期间重复出现呼吸道阻塞.
- 过度的白天嗜睡 (EDS) 是OSA的常见症状,严重影响患者的生活质量.
- OSA,EDS和认知功能之间的关系需要进一步研究,特别是在特定的人口群体中.
研究的目的:
- 检查过度白天嗜睡 (EDS) 对中国阻塞性睡眠呼吸暂停 (OSA) 患者认知功能的影响.
- 为了比较中度至重度OSA患者和轻度OSA或初级打患者之间的认知表现.
主要方法:
- 该研究包括中国成年人中度至重度OSA (AHI ≥15) 和初级打/轻度OSA (AHI <15).
- 使用爱普沃思睡眠度量表 (ESS) 评估过度睡眠.
- 认知功能使用迷你精神状态检查 (MMSE) 和蒙特利尔认知评估 (MOCA) 进行评估.
主要成果:
- 与轻度OSA/打组 (n=635) 相比,中度至重度OSA患者 (n=1423) 是年长的,主要是男性,ESS得分,BMI和氧气脱度 (ODI) 较高.
- 患有中度至重度OSA的患者的教育程度较低,动脉氧和度最低 (min-SaO2) 降低,睡眠结构改变 (SWS和REM减少).
- 在中度至重度的OSA组中,延迟回忆得分明显较低,而爱普沃思睡眠度量表 (ESS) 得分是与这种缺陷相关的主要因素.
结论:
- 中度至重度的OSA与认知功能障碍有关,特别是受损的延迟回忆.
- 过度白天嗜睡 (EDS),如ESS得分较高所示,与年轻和中年OSA患者的认知障碍有显著联系.
- 这些发现强调了在OSA患者中管理EDS的重要性,以潜在地减轻认知缺陷.
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