与轻度认知障碍和行为现象型相关的认知和身体年龄差距
Junhong Yu1, Ted Kheng Siang Ng2,3, Rathi Mahendran4,5
1Psychology, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue, 639798, Singapore, Singapore. junhong.yu@ntu.edu.sg.
GeroScience
|July 10, 2023
概括
通过年龄差距来衡量加速的认知和身体衰老,与老年人轻度认知障碍 (MCI) 和较差的福祉有关. 这项研究验证了MCI诊断的认知年龄差距.
科学领域:
- 老年学和认知科学 认知学和认知科学
- 生物医学数据科学 生物医学数据科学
背景情况:
- 生物衰老时钟通过将基于机器学习的生物年龄与时间年龄进行比较来估计衰老速度,从而产生"年龄差距".
- 认知和身体年龄差距与行为因素,特别是轻度认知障碍 (MCI) 之间的关联仍未得到充分研究.
研究的目的:
- 调查与轻度认知障碍 (MCI) 相关的认知和身体年龄差距,以及社区老年人的行为表型.
- 验证认知年龄差距在诊断MCI中的有用性.
主要方法:
- 开发并验证了机器学习模型,用于使用认知测试和身体健康评分来预测认知和身体年龄.
- 计算了822名老年人的认知和身体年龄差距.
- 他们比较了患有MCI和没有MCI的个体之间的年龄差距,并将其与17种行为表型 (生活方式,幸福感,态度) 相关联.
主要成果:
- 与认知正常个体相比,较大的认知年龄差距与MCI显著相关.
- 认知和身体年龄差距与更糟糕的幸福感和更负面的态度相关.
- 认知和身体年龄差距显著相互相关.
结论:
- 通过年龄差距来表明,加速的认知和身体衰老与不良的心理健康和负面态度有关.
- 这些发现加强了认知和身体衰老过程的相互联系.
- 认知年龄差距显示出作为MCI诊断的验证工具的希望.
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