美国成人和儿童多发性硬化症疾病修饰疗法的启动模式,2001年至2020年
Mackenzie Henderson1, Daniel B Horton1,2,3, Vikram Bhise2,4
1Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey.
JAMA neurology
|July 10, 2023
概括
治疗多发性硬化症 (MS) 的口腔疾病修饰疗法 (DMT) 的使用率从2010年的1.1%升至2020年的62.3%. 在此期间,注射性DMT的开始率大幅下降.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 多发性硬化症 (MS) 治疗方法已经发展,在过去二十年中批准了许多疾病修饰疗法 (DMT).
- 关于这些批准如何影响MS管理的处方模式的现实数据有限.
研究的目的:
- 分析2001年至2020年美国成年人和患有多发性硬化症的儿童中DMT启动的趋势.
- 了解DMT处方模式随时间的推移而发生的变化.
主要方法:
- 一个连续的横截面研究利用美国商业索赔数据 (MarketScan) 从2001-2020.
- 在成年人中确定了153,846次DMT启动事件,在患有MS的儿童中确定了583次.
主要成果:
- 在成年人中,注射性DMT的开始,特别是干扰素β,显著下降了73.8%.
- 口服DMT的使用率从2010年的1.1%急剧上升至2020年的62.3%.
- 输液治疗的启动率仍然很低,但在2017年之后略有增加,到2020年达到8.2%.
结论:
- 口服DMT成为2020年开始的MSMS治疗的主要类型.
- 转向口腔疗法可能会受到诸如方便,广告或保险等因素的影响.
- 这一趋势凸显了MS治疗策略的显著演变.
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