相关实验视频

Updated: Jul 24, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

基于In Situ Cu2+ Di-Chelation 的增强pH响应化学/化学动力协同癌症疗法

Minghua Zhou¹, Beibei Tian¹, Yingcui Bu¹

¹College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Anhui University, Hefei 230601, P.R. China.

ACS applied bio materials

|July 10, 2023

概括

这项研究介绍了一个智能纳米平台,用于增强癌症治疗. 响应pH的纳米颗粒将药物和铜离子输送到瘤微环境中,从而实现协同化学/化学动力学治疗,以显著消除瘤.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

化学动力学疗法和化疗对癌症治疗有希望.
为增强协同疗法开发刺激响应纳米平台至关重要.

研究的目的:

设计一个pH响应的纳米平台,用于增强化学/化学动力学协同的癌症治疗.
调查现场Cu2+二化策略,以提高治疗疗效.

主要方法:

合成了PEGylated mesoporous CuO纳米粒子 (PEG-CuO@DSF@MTONP),封装了二硫 (DSF) 和线粒 (MTO).
这些纳米颗粒被设计为在酸性瘤微环境 (TME) 中释放Cu2+,DSF和MTO.
在体内小鼠模型被用来评估协同治疗效果.

主要成果:

酸性TME诱导了纳米粒子崩和活性成分 (Cu2+,DSF,MTO) 的释放.
在Cu2+与DSF和MTO的局部复合显著增强化疗和启动化学动力学治疗.
在体内小鼠模型中观察到显著的瘤消除.

结论:

开发的智能纳米系统证明了有效的化学/化学动力学协同疗法.
这一战略为设计具有临床转化潜力的先进癌症纳米疗法提供了一个有前途的方法.

关键词:

这是一种二硫胺.增强化学疗法/化学动力学在现场Cu2+二化.半孔 CuO 的 CuO 的 CuO 的 CuO.这种药物是Mitoxantrone.协同效应疗法是一种协同效应疗法.

更多相关视频

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

相关概念视频

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...