与老年人常规护理相比,捆绑式高多药药处方的有效性:一项随机临床试验
Lisa J Herrinton1, Keras Lo2, Mubarika Alavi1
1Division of Research, Kaiser Permanente Northern California, Oakland.
JAMA network open
|July 10, 2023
概括
对高多药性老年人的抑郁症干预措施并没有减少药物使用或老年综合征. 在不太完整的环境和目标人群中需要进一步的研究.
科学领域:
- 老年学是一门学科.
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 使用多种处方药 (超多药) 的老年患者面临药物不良影响的风险增加.
- 需要有效的干预措施来管理多重药学和改善患者的治疗结果.
研究的目的:
- 评估质量改善干预措施的有效性和安全性,旨在减少老年人中超多药性.
- 评估干预对药物负担,老年综合征和医疗保健利用的影响.
主要方法:
- 一项随机临床试验,涉及76岁或以上的患者,服用10种以上药物.
- 干预组在180天内通过电话接受了医生和药剂师协作药物治疗管理.
- 对照组在综合卫生系统中接受了通常的护理.
主要成果:
- 在干预和常规护理组之间,发放药物的平均变化没有显著差异 (-0.4对 -0.4).
- 与通常的护理相比,干预措施并没有显著降低老年综合征 (跌倒,认知,失禁,疼痛) 的患病率.
- 两组之间在使用医疗服务或药物戒断不良影响方面没有观察到差异.
结论:
- 在综合护理环境中,捆绑的抑郁症干预措施并没有有效地减少药物处方或老年综合征.
- 这些发现表明,目前的抑郁症策略可能需要改进或适应不同的医疗保健环境.
- 在不太完整的环境和更具体的患者群体中,进一步的研究是有必要的,以优化抑郁症的努力.
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