癌症在生长激素过量和生长激素不足中的癌症
Jaime Guevara-Aguirre1,2,3, Gabriela Peña1, William Acosta1
1Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador.
Endocrine-related cancer
|July 10, 2023
概括
增长激素 (GH) 过量与癌症风险增加有关,而GH缺陷会降低癌症风险. 患有拉伦综合征的个体,表现出低GH和胰岛素样生长因子-I (IGF-I) 信号,癌症发病率显著降低.
科学领域:
- 内分泌学和瘤学的内分泌学和瘤学.
- 分子生物学分子生物学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 生长激素 (GH) 过量与癌症之间的关联仍在争论中,研究将巨与各种瘤联系起来.
- 相反,患有GH和胰岛素样生长因子-I (IGF-I) 缺陷的情况与癌症发病率降低相关.
- 影响GH/IGF-I通路或瘤抑制基因的遗传突变会影响致癌.
研究的目的:
- 研究GH和IGF-I信号在癌症发展中的作用.
- 探索低GH/IGF-I信号和相关的代谢变化对癌症发病率的影响.
- 评估在拉伦综合征中观察到的对恶性瘤的保护作用.
主要方法:
- 审查关于GH,IGF-I和癌症关联的现有文献.
- 分析了壮病和GH/IGF-I缺乏症患者的临床数据.
- 对厄瓜多尔患有拉伦综合征 (ELS) 的队列中发现的检查.
主要成果:
- 研究表明,在GH过多的情况下,结肠癌,甲状腺癌,胃癌,乳腺癌和尿道癌的风险增加.
- 患有GH/IGF-I缺陷的个体表现出恶性瘤发病率降低.
- 拉伦综合征患者,尽管肥胖,表现出正常血糖和低胰岛素,与减少的癌症发病率相关.
结论:
- 低IGF-I和胰岛素血清水平,如在拉伦综合征中所见,可能会提供对癌症的保护.
- 高血糖和高胰岛素是细胞增殖的关键,包括瘤生长.
- 胰岛素/INSR信号传递是GH/IGF-I相关生理和病理事件的关键代谢枢纽.
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