心脏病学和肺病学之间的智力利益冲突临床实践指南
J Henry Brems1,2, Taylor Wagner2, Julia Diamant2
1Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
PloS one
|July 10, 2023
概括
智力利益冲突 (COI) 在心脏病学和肺病学临床实践指南 (CPG) 中很常见. 需要改进管理策略,以确保这些重要的医疗文件的有效性和可信性.
科学领域:
- 医学指导方针 医学指导方针
- 利益冲突研究研究 利益冲突
- 心脏病学和肺部病学
背景情况:
- 智力利益冲突 (COI) 可以损害临床实践指南 (CPG) 的有效性和可信性.
- 关于CPG中知识产权COI的流行和管理的数据有限.
- 这项研究解决了关于心脏病学和肺病学CPG智力COI的知识差距.
研究的目的:
- 估计心脏病学和肺病学CPG的作者中智力COI的流行率.
- 评估本指南中用于知识产权COI的管理策略.
- 为了比较心脏病学和肺病学CPGs之间的智力COI的患病率和管理.
主要方法:
- 从2018-2019年开始对CPG进行了回顾性文档审查.
- 从美国,加拿大和欧洲的专业协会中确定了CPG.
- 评估的作者是知识产权的COI (对审查的研究,社论或之前的CPG的作者) 和管理策略 (例如,GRADE,方法学家的纳入,反驳).
主要成果:
- 在39名CPG和737名作者中,64%的作者至少有一位智力COI.
- 在所有CPG中,平均67%的作者具有智力COI.
- 心脏病学CPG显示智力COI患病率 (84%) 比肺病学CPG (57%) 高.
- 管理策略如GRADE (64%) 和方法学家纳入 (49%) 的使用率有所变化;对智力COI的拒绝率为0%.
结论:
- 智力利益冲突在心脏病学和肺病学CPG中非常普遍,但报告不足.
- 这种流行率对CPG建议的有效性构成潜在威胁.
- 由指导方针制订组织加强对知识产权COI的关注和管理是至关重要的.
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