临床医生关于SEER口腔癌生存率计算器的关键点
Louise Davies1,2, Benjamin F Hankey3, Zhuoqiao Wang4
1VA Outcomes Group, US Department of Veterans Affairs Medical Center, White River Junction, Vermont.
JAMA otolaryngology-- head & neck surgery
|July 10, 2023
概括
口腔癌患者面临来自其他健康状况的重大风险,而不仅仅是他们的癌症. 一个新的计算器有助于估计生存率,考虑癌症和竞争风险,以获得更好的患者护理.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 癌症患者往往有并发症,这会显著影响存活率.
- 口腔癌患者经常接触酒精和烟草,面临来自竞争死亡原因的高风险.
- 这些相互竞争的风险可能与癌症本身一样危及生命,甚至比癌症本身更危及生命.
研究的目的:
- 为公众推出一种新型计算器,用于估计口腔癌患者的存活率.
- 为提供健康状况调整后的年龄,预期寿命和因口腔癌死亡的概率与其他原因的个性化预测.
- 强调在口腔癌预后中考虑竞争风险的重要性.
主要方法:
- 开发一个计算器,利用来自监测,流行病学和最终结果 (SEER) 计划的数据.
- 在预后模型中包括患者年龄 (20-86岁) 和癌症阶段.
- 统计技术允许分析两个时间尺度 (癌症特异性死亡和其他原因死亡).
主要成果:
- 与美国普通人口相比,患有口腔癌的患者因癌症以外的其他原因死亡的风险高于平均水平.
- 这种竞争性死亡率的高风险随着口腔癌的发展阶段而增加.
- 该计算器提供了诊断后1至10年内生存概率的估计.
结论:
- SEER口腔癌生存率计算器通过同等权衡癌症特异性和竞争性死亡风险,促进了对患者护理的整体方法.
- 这个工具可以与现有的口腔癌预后计算器一起使用.
- 该计算器例证了将注册表数据与先进的统计方法联系起来,以进行全面的生存分析的潜力.
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