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哥伦比亚转换抗逆转录病毒药物的原因:一项回顾性队列研究
Sandra Liliana Valderrama-Beltrán1,2, Samuel Martínez-Vernaza1,2, Shirley Vanessa Correa-Forero1
1Division of Infectious Diseases, Department of Internal Medicine, School of Medicine. Research Group on Infectious Disease, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia.
International journal of STD & AIDS
|July 10, 2023
概括
药物不耐受是哥伦比亚HIV患者转换抗逆转录病毒疗法 (ART) 的主要原因. 与其他国家相比,由于不耐受性而改变ART的时间较短,这凸显了在最初的ART疗法中需要更好的耐受性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 长期使用抗逆转录病毒疗法 (ART) 治疗艾滋病毒感染往往需要改变治疗方案.
- 了解影响ART开关的原因和因素对于优化患者护理和治疗结果至关重要.
研究的目的:
- 分析哥伦比亚艾滋病毒队列中转换ART治疗方案的原因.
- 为了确定不同原因和相关因素的切换时间.
- 将研究结果与有关ART转换的国际报告进行比较.
主要方法:
- 在哥伦比亚的20家艾滋病毒诊所进行了回顾性队列研究.
- 纳入标准:在2017年1月至2019年12月期间切换ART的HIV阳性成年人 (≥18岁).
- 统计分析包括时间到事件分析和探索性考克斯模型.
主要成果:
- 796名参与者在研究期间切换了ART.
- 药物不耐受是ART转换的主要原因 (56.4%),转换的中位数时间为12.2个月.
- 简化治疗方案导致最长的中位时间转换 (42.4个月).
- 年龄≥50岁的个体和在CDC第3阶段被诊断的个体,转换ART的风险较低.
结论:
- 在这个哥伦比亚队列中,药物不耐受是ART疗法转换的主要驱动因素.
- 由于哥伦比亚的不耐受性,转换ART的中位数时间比国际上报告的要短.
- 在哥伦比亚,强调目前对ART启动的建议,重点关注具有更好的耐受性概况的疗法,至关重要.
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