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装载着阿齐思罗米的多分子微粒作为潜在的肺部药物递送系统:物理化学性质,抗菌行为和细胞兼容性研究

Karolina Knap¹, Katarzyna Reczyńska-Kolman¹, Konrad Kwiecień¹

¹AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, Al. Mickiewicza 30, 30-059 Kraków, Poland.

Biomaterials advances

|July 10, 2023

概括

装有阿齐思罗米的可降解的多分子微粒提供了一个有希望的粉末配方,用于局部的肺部输送. 这些微粒显示出有效的抗菌性质和良好的细胞相容性,用于治疗肺部感染.

科学领域:

生物材料科学生物材料科学
制药科学制药科学
传染性疾病传染性疾病

背景情况:

复发性细菌感染是囊性纤维化和慢性阻塞性肺病患者死亡的重要原因.
有效的局部药物输送到肺部仍然是管理这些感染的挑战.

研究的目的:

开发和表征可降解的多脂酸 (PSA) 微粒,载有阿兹胺素 (AZ),用于肺部输送.
评估装载AZ微粒的物理化学特性,抗菌疗效和细胞毒性.

主要方法:

用不同度的阿齐思罗米辛制造了多样性 (脂酸) 微粒.
描述包括PBS中的尺寸,形态,泽塔潜力,封装效率和降解研究.
使用Kirby-Bauer方法对黄金葡萄球菌的抗菌活性进行了评估.
在BEAS-2B和A549肺上皮细胞中评估了细胞毒性.

主要成果:

微粒是球形的,尺寸 (1-5微米) 适合肺部输送.
在所有配方中,阿齐思罗米封装效率接近100%.
微粒物呈现出快速降解 (大约为2~3个小时). 在24小时内损失了50%的质量) 并释放了活性阿齐思罗米.
观察到有效抑制金黄色葡萄球菌的生长,微粒的安全度为50μg/ml.

结论:

开发出来的多脂酸微粒具有有利的物理化学性质,可用于局部的肺部输送.
微粒显示有控制的降解,有效的药物释放,细胞相容性和强大的抗菌活性.
这些发现表明这种微粒子配方在局部治疗肺部感染方面的潜力.

关键词:

亚齐思罗密辛是一种亚齐思罗密辛.干粉用于吸入的干粉.微粒微粒的使用方法聚脂 (多脂) 是一种多脂 (多脂) 酸.聚化的使用方法

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