在患者退伍军人中使用心理药物的模式:药物相互作用是否重要?
Barry E Gidal1, Rizwana Rehman2, Tung Tran2
1University of Wisconsin Madison School of Pharmacy, Madison, WI, USA.
诱导酶的抗发作药物 (ASM) 在患者中没有导致更高的精神药物剂量或更频繁的药物调整. 这些发现表明,潜在的药理动力学相互作用可能不会显著影响临床结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 患者经常经历精神病并发症,如抑郁和焦虑,需要多种精神药物治疗.
- 已知诱导酶的抗发作药物 (EIASM) 会增加其他药物的清除,可能会影响其疗效.
- EIASM与精神药物 (PD) 之间的药理动力学 (PK) 相互作用的临床意义仍然不清楚.
研究的目的:
- 量化EIASM与非诱导性抗发作药物 (NIASM) 对临床使用替代标记物的影响.
- 检查结果的抗抑郁药 (AD) 或抗精神病药 (AP) 剂量,组合治疗频率和PD切换频率.
- 测试EIASM治疗与更高的PD剂量和由于PK相互作用而更频繁的Rx调整相关的假设.
主要方法:
- 从2010年至2014年对VA药房和患者退伍军人的遭遇数据库进行了回顾性分析.
- 至少365天同时服用抗发作药物 (ASM) 和精神药物 (PD) 的确定的患者.
- 通过奇平方测试,将接受EIASM和NIASM的患者与AD/AP剂量,组合疗法和PD切换频率进行了比较.
主要成果:
- 确定了16188名患者,57.0%接受了EIASM,43.0%接受了NIASM.
- 较高比例的EIASM患者接受单一治疗 (42.0%与36.1%相比).
- 与假设相反,EIASM和NIASM组之间的平均AD/AP剂量没有差异;组合治疗 (AD+AP) 在NIASM患者中更高.
结论:
- 同时使用精神药物在患者中很常见,许多人仍然在EIASM上.
- EIASM和PD之间的PK相互作用可能不会导致剂量或多疗法的临床上有意义的差异.
- 需要对临床精神病学结果测量进行进一步的研究来证实这些发现.
更多相关视频
09:16Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
Published on: June 21, 2019
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
相关概念视频
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
