在FLASH辐射疗法条件下,用质子辐射的水的发光成像
Katsunori Yogo1, Satoshi Kodaira2, Tamon Kusumoto2
1Graduate School of Medicine, Nagoya University, 1-1-20 Daiko-minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan.
Physics in medicine and biology
|July 10, 2023
概括
水的发光成像有效地可视化了超高剂量率 (UHDR) 质子束辐射疗法的剂量分布. 这种方法为FLASH质子疗法提供了快速,无膜的质量保证,确保精确的剂量测量.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 图像技术技术的成像技术
背景情况:
- 闪光辐射疗法利用超高剂量率 (UHDR) 潜在地节省正常组织,同时保持抗瘤作用.
- 精确的剂量分布测量对于UHDR质子束疗法至关重要,但存在技术上的挑战.
- 目前在UHDR质子疗法中剂量测量的方法通常是缓慢和复杂的.
研究的目的:
- 调查使用水的发光成像来测量UHDR质子束剂量分布的可行性.
- 评估在UHDR条件下发光成像的剂量速率依赖性和配置精度.
- 评估该技术在质子FLASH疗法质量保证方面的潜力.
主要方法:
- 用60 MeV和139.3 MeV的质子束在0.03至4 320 Gy/s的剂量速率下对水进行辐射,使用循环子和同步子系统.
- 使用充电合装置摄像机捕获发光图像.
- 在UHDR和常规剂量速率光束之间比较发光强度和配置.
主要成果:
- 在UHDR质子辐射下清晰可视化水的发光,与传统光束相比,显著减少了暴露时间.
- 观察到发光光强度和输送剂量之间的线性关系,与传统光束相一致.
- 在测试范围 (0.03-837 Gy/s) 内的光强度没有发现显著的剂量-速率依赖.
- UHDR和常规光束之间的光强度配置文件一致,无论加速器类型或光束能量如何.
结论:
- 对水的发光成像是一种可行的技术,用于用高强度高强度 (UHDR) 质子束测量剂量分布.
- 该方法提供实时,无膜剂量分配数据,适合在质子FLASH治疗中快速质量保证.
- 这种技术为优化质子FLASH疗法协议提供了有效和准确的反.
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