对微乳液系统进行研究,用于通过透增强剂通过皮肤输送瑞斯龙
Amitkumar Virani1, Nirali Dholaria1, Namrata Matharoo1
1Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, United States; Center for Dermal Research, Rutgers-The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, United States.
Journal of pharmaceutical sciences
|July 10, 2023
概括
这项研究开发了带有透增强剂的微乳液,用于通过皮肤递送瑞斯佩里. 优化的配方显著增加了RISPERIDONE的透,显示了有效的皮肤间药物递送的潜力.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤递送的药物在某些药物上比口服药物更有优势.
- 抗精神病药物里斯佩里在有效的透皮输送方面面临挑战.
- 微乳液是增强通过皮肤透药物的有希望的载体.
研究的目的:
- 开发和表征微乳液配方,用于通过皮肤输送瑞斯.
- 为了评估透增强剂在改善RISPERIDONE透中的有效性.
- 为了比较各种微乳液配方的通过皮肤传递潜力.
主要方法:
- 准备瑞斯佩里配方,包括对照剂和各种含透增强剂的微乳液.
- 针对球体大小,多分散度指数和pH的微乳液的表征.
- 使用人体尸体皮肤和弗兰茨扩散细胞进行ex-vivo透研究.
主要成果:
- 一个优化的微乳液 (15%的油酸,15%的Tween 80,20%的异醇,50%的水) 显示出优异的RISPERIDONE透.
- 这种配方实现了32.50±3.60 ug/hr/sq.cm的流量,球体大小为2.96±0.01 nm.
- 与对照配方相比,Risperidone的透率提高了14倍.
结论:
- 包括透增强剂的优化微乳液显著改善了通过皮肤递送瑞斯的传递.
- 这些发现表明微乳液是一种可行的策略,用于开发有效的透皮瑞斯佩里系统.
- 进一步的研究可能会验证微乳液用于临床透皮抗精神病治疗.
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