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在糖尿病病中,NAD代谢调节炎症和线粒体功能

Komuraiah Myakala¹, Xiaoxin X Wang¹, Nataliia V Shults¹

¹Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of Columbia, USA.

The Journal of biological chemistry

|July 10, 2023

概括

尼古丁胺基核糖胺 (NR) 补充剂增强NAD+代谢,改善线粒体功能和减少炎症,以防止糖尿病病在小鼠中的进展.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
代谢疾病代谢疾病
线粒体生物学线粒体生物学

背景情况:

糖尿病病 (DKD) 是糖尿病的一个主要并发症,导致显著的心血管和病率.
炎症和氧化应激是DKD的关键驱动因素,线粒体损伤起着关键作用.
线粒体代谢和DKD炎症之间的联系需要进一步阐明.

研究的目的:

调查增强尼古丁胺氨酸核酸 (NAD+) 代谢的潜力,以防止炎症和DKD进展.
为了测试尼古丁胺二化物 (NR) 可以改善2型糖尿病小鼠模型中的功能障碍的假设.

主要方法:

治疗db/db小鼠 (一种2型糖尿病的模型) 用尼古丁胺胺 рибоoside (NR).
评估功能障碍标志物,包括白蛋白尿和尿损伤标志物-1 (KIM1).
评估炎症,线粒体功能,NAD+代谢,以及干扰素基因 (cGAS-STING) 循环GMP-AMP合成酶刺激通路.

主要成果:

NR治疗可以预防功能障碍,减少白蛋白尿和KIM1分泌.
通过抑制cGAS-STING信号通路,NR的使用降低了炎症.
NR增加了SIRT3活性,改善了线粒体功能,并减少了线粒体DNA损伤.

结论:

通过NR促进NAD+代谢,可以保护小鼠免受DKD的进展.
通过改善线粒体功能和通过cGAS-STING通路减少炎症来调解NR的保护作用.
准NAD+代谢是一种有前途的治疗策略,用于治疗糖尿病病.

关键词:

在这里,我们可以看到NAD,NAD,NAD.cGAS-STING 的使用情况.糖尿病病糖尿病病炎症,糖尿病以及其他疾病.线粒体中的线粒体.线粒体DNA损伤导致的DNA损伤.塞尔图因 3 3

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