在一个前性,观察性队列研究中使用旋转血栓等位测量对COVID-19相关的凝血病的鉴定:HemoCoV研究:HemoCoV研究
Anabela Rodrigues1, Tiago Dias Domingues2, Gustavo Nobre Jesus3
1Transfusion Medicine Department. Hospital Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisbon. Portugal.
Acta medica portuguesa
|July 10, 2023
概括
严重的COVID-19会导致高凝血和低纤维素溶解的凝血病,在重症监护室 (ICU) 停留期间持续存在. 这些血液凝结问题在未幸存者中更为严重.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- COVID-19感染与凝血病有关,其特征是系统性炎症,内皮功能障碍和免疫血栓形成.
- 了解中度至重度COVID-19的特定凝血异常对于患者管理至关重要.
研究的目的:
- 在重症患者中描述与SARS-CoV-2感染相关的凝血病.
- 为了调查在重症监护室 (ICU) 住院期间凝血参数的变化.
主要方法:
- 在145名中度至重度COVID-19患者中进行了一项开放标签,前性观察性研究,需要接受ICU治疗.
- 凝血测试,生物化学分析和临床变量在30天内纵向收集.
主要成果:
- 研究人口的平均年龄为68岁,患有包括高血压,肥胖和糖尿病在内的共同疾病.
- 血栓和出血事件分别发生在22.1%和15.1%的患者中. 观察到高凝血和低纤维素分解,特别是在未幸存者中.
- 在ICU入院和出院之间,凝血参数存在显著差异,存在持续异常.
结论:
- 与COVID-19相关的凝血病呈现出高凝血性和从ICU入院后的低纤维素溶解.
- 这些凝血障碍在严重的COVID-19的临床过程中持续存在.
- 凝血病的严重程度与疾病负担相关,并且在未幸存者中更为明显.
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