在炎症性肠道疾病中观察和等待直肠癌
José Gonçalves Moreira de Azevedo1, Laura Fernandez2, Alberto Ignacio Herrando2
1Department of Digestive Surgery, Champalimaud Foundation, Lisboa, Portugal jgmazevedo@gmail.com.
BMJ case reports
|July 10, 2023
概括
观察和等待 (WW) 为直肠癌患者提供器官保存,这些患者对新辅助治疗有完全的反应. 这种策略可以避免手术并发症,但需要严格监测潜在的再生,特别是在炎症性肠病患者.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 炎症性肠病 (IBD) 显著增加了CRC的风险.
- 器官保存策略,包括观察和等待 (WW),正在出现用于直肠癌管理.
研究的目的:
- 在患有炎症性肠道疾病和直肠癌的患者身上展示一个Watch and Wait的案例.
- 要突出评估IBD患者在战后的挑战.
- 讨论IBD患者放射治疗的风险和IBD患者的CRC监测困难.
主要方法:
- 案例报告的呈现方式.
- 对新辅助剂治疗反应评估的审查.
- 讨论监测协议和瘤学结果.
- 探索IBD患者经历WW的特定挑战.
主要成果:
- 没有关于观察和等待IBD患者与直肠癌的文献.
- IBD使患者的评估和放射治疗使用复杂化.
- 严格的监测对于检测局部再生至关重要,这可能需要推迟手术.
结论:
- 观察和等待是一种可行的器官保存策略,用于选择直肠癌患者.
- 在IBD患者中应用WW提出了独特的挑战,需要仔细考虑.
- 需要进一步的研究,以建立最佳的WW协议IBD患者与直肠癌.
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