非洲的先天性异常和风险因素:系统审查和元分析
Natnael Moges1, Denekew Tenaw Anley2, Melkamu Aderajew Zemene2
1Department of Pediatrics and Child Health Nursing, College of Health sciences, Debre Tabor University, Debre Tabor, Ethiopia natumoges611@gmail.com.
BMJ paediatrics open
|July 10, 2023
概括
在非洲,每1000名新生儿中有23.5名患有先天性异常. 危险因素包括不服用叶酸,孕产妇疾病,吸毒,孕产妇晚年,酒精,口和城市居住.
科学领域:
- 公共卫生 公共卫生
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 先天性异常是全球重要的健康问题,特别是在资源较低的环境中.
- 了解患病率和风险因素对于在非洲开发有针对性的干预措施至关重要.
研究的目的:
- 确定非洲新生儿中先天性异常的综合流行率.
- 确定与非洲人口的先天性异常相关的关键风险因素.
主要方法:
- 一项系统性审查和对32项涉及626,983名参与者的研究的元分析.
- 搜索到2023年1月的多个数据库;使用JBI评估检查表和STATA V.17进行分析.
- 利用DerSimonian和Laird随机效应模型进行聚合流行,用I2和Egger的测试来评估异质性和偏差.
主要成果:
- 生产异常的综合患病率为每1000名新生儿中有23.5 (95% CI: 20-26.9).
- 确定的重大风险因素包括:缺乏叶酸摄入量 (OR=2.67),母亲的疾病 (OR=2.44),吸毒 (OR=2.74),母亲的年龄>35 (OR=1.97),酒精消费 (OR=3.15), (OR=3.34),以及城市居住 (OR=0.58).
结论:
- 在非洲,先天性异常的大量综合流行需要有针对性的公共卫生战略.
- 干预措施应强调叶酸补充,孕产妇健康管理,产前护理,谨慎使用药物,避免饮酒和.
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