内巴尼图马布和近视性黄斑变性
Mukharram M Bikbov1, Gyulli M Kazakbaeva1, Frank G Holz2
1Ufa Eye Research Institute, Ufa, Russian Federation.
The British journal of ophthalmology
|July 10, 2023
概括
作为EGFR抑制剂的帕尼图穆巴 (Panitumumab) 在对病态近视的第一阶段研究中显示出良好的眼内耐受性. 重复的静脉内注射没有引起不良反应或改变轴长度.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 实验研究表明,针对表皮生长因子受体 (EGFR) 的抗体可以减少眼睛的延长.
- 帕尼图穆马布是一种针对EGFR的全人类单克隆IgG2抗体,用于瘤学.
- 这项研究调查了panitumumab在治疗病理近视的轴延长方面的安全性.
研究的目的:
- 为了评估眼内耐受性和安全性,内巴尼图穆马布.
- 评价帕尼图穆马布作为一种潜在的治疗方法,用于治疗患有病理近视症的成年人眼睛的轴延长.
主要方法:
- 一个单一的中心,开放的标签,第一阶段研究.
- 11名患有第四期近视性黄斑退行症的患者接受了静脉直肠巴尼图马布注射.
- 剂量从0.6毫克到1.8毫克不等,注射间隔不同.
主要成果:
- 没有观察到治疗引起的系统性不良事件或眼内炎症.
- 最好的视力敏度和眼内压力保持稳定.
- 在3个月以上的随访后,患者的轴长度没有显著变化.
结论:
- 重复内注射至1.8毫克的帕尼图穆马布是安全的,并且耐受良好.
- 没有发现眼内或全身的不良影响.
- 在研究期间,轴长保持不变.
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