纤维肌痛和死亡率:一个系统审查和元分析
Yulia Treister-Goltzman1,2, Roni Peleg3,2
1Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel yuliatr@walla.com.
RMD open
|July 10, 2023
概括
这一系统性审查发现,纤维肌痛与所有原因死亡率的增加有关. 纤维肌痛患者面临更高的感染和自杀死亡风险,强调需要认真临床关注.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 纤维肌痛是一种慢性疾病,具有广泛的疼痛和疲劳的特征.
- 纤维肌痛对患者死亡率的影响仍然是一个需要进一步研究的领域.
研究的目的:
- 系统地审查和分析有关纤维肌痛和死亡率之间的关联的现有文献.
- 量化纤维肌痛患者全因和因特定死亡的风险.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了全面的文献搜索.
- 符合条件的研究报告纤维肌痛和死亡率的效果测量 (HR,SMR,OR) 被纳入系统性审查和元分析.
- 偏差风险使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 分析包括8项研究,包括188,751名纤维肌痛患者.
- 观察到所有原因死亡率的危险比率 (HR) 增加 (HR 1.27).
- 感染 (SMR 1.66) 和自杀 (SMR 3.37) 的标准化死亡率 (SMR) 较高,而癌症死亡率显示SMR (0.82) 降低.
结论:
- 纤维肌痛与增加全因死亡率有关.
- 在纤维肌痛患者中,感染和自杀的死亡风险增加.
- 临床管理人员应优先考虑对自杀念头的查,事故预防和感染管理.
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