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Updated: Jul 24, 2025

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique
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一个小鼠模型,用于在胰腺中高效的Flp-重组酶介导的基因操纵

Xiaohui Zhu1, Jiaxiang Chen1, Bin Wang1

  • 1Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
|July 10, 2023
PubMed
概括

研究人员开发了一种新的FLPo复合酶系统,用于精确地向胰腺中的基因. 该系统可实现双重重组合,用于先进的胰腺研究和癌症建模.

关键词:
动物模型动物模型癌症 癌症 癌症 癌症双重重组合酶的使用胰腺是什么? 胰腺是什么?在Pdx1-FlpOO中使用.

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Conservative Site-specific Recombination and Phase Variation02:53

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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