IL-9会加剧SARS-CoV-2感染,并加剧相关的呼吸道炎症
Srikanth Sadhu1,2, Rajdeep Dalal1, Jyotsna Dandotiya1
1Centre for Immunobiology and Immunotherapy, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121 001, Haryana, India.
Nature communications
|July 10, 2023
概括
介素9 (IL-9) 加剧了SARS-CoV-2感染和呼吸道炎症. 阻止IL-9或准Foxo1-IL-9通路可能会减轻COVID-19的严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- SARS-CoV-2 导致支气管支气管炎症.
- 介质蛋白9 (IL-9) 与其他疾病的呼吸道炎症有关,但其在COVID-19中的作用尚不清楚.
研究的目的:
- 为了研究IL-9在SARS-CoV-2感染和COVID-19病变发生中的作用.
- 在SARS-CoV-2感染期间探索T细胞中的叉头盒蛋白O1 (Foxo1) -IL-9通路.
主要方法:
- 使用K18-hACE2转基因小鼠模型感染SARS-CoV-2.
- 检查了患有CD4+T细胞特异性Foxo1.1缺乏症的小鼠.
- 施用外源性IL-9和IL-9阻断剂.
主要成果:
- 在感染SARS-CoV-2的小鼠中,IL-9会加剧病毒传播和呼吸道炎症.
- 缺乏FOXO1的小鼠产生较少的IL-9并且对严重的COVID-19有抗性.
- 在受感染的小鼠中,IL-9阻塞减少了呼吸道炎症.
结论:
- 一个Foxo1-IL-9介导的T细胞通路有助于COVID-19的发病.
- 阻断IL-9和准这种途径是潜在的宿主导向COVID-19的治疗策略.
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