唐氏综合征儿童的阻塞性睡眠呼吸暂停:上呼吸道和化学敏感性的贡献
Plamen Bokov1, Imene Boujemla2, Jacques Dahan3
1Université de Paris-Cité, AP-HP, Hôpital Robert Debré, Service de Physiologie Pédiatrique-Centre du Sommeil, INSERM NeuroDiderot, F-75019, Paris, France. plamen.bokov@aphp.fr.
Pediatric research
|July 10, 2023
概括
患有唐氏综合征 (DS) 和阻塞性睡眠呼吸暂停综合征 (OSAS) 的儿童的呼吸道较小,外周化学敏感性降低,导致低通风. 这项研究比较了DS儿童的气道大小和通风控制,与典型发育的OSAS儿童相比.
科学领域:
- 儿科肺病学 儿科肺病学
- 遗传学和遗传性疾病
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 在患有唐氏综合征 (DS) 的儿童中非常普遍,通常与上呼吸道尺寸减少有关.
- 通风控制对DS中OSAS的贡献仍然不清楚.
研究的目的:
- 将DS和中度至重度OSAS儿童的上呼吸道尺寸与具有类似OSAS严重性的典型发育 (TD) 儿童进行比较.
- 评估DS儿童化学循环增益 (LG) 的修改,包括控制器增益 (CG) 和植物增益 (PG).
主要方法:
- 一项病例对照研究将13名DS儿童与26名TD儿童根据年龄,性别,OSAS严重程度和种族进行了匹配.
- 方法包括声学鼻测,喉测,对化学LG进行清醒的潮呼吸测量,以及超 - 超氧呼吸反应测试.
主要成果:
- 与TD儿童相比,DS儿童的口腔大尺寸减少.
- 在患有DS的儿童中,观察到控制器增益 (CG) 和循环增益 (LG) 显著较低,而植物增益 (PG) 并没有不同.
- 超呼吸呼吸器反应斜率在两组之间没有差异.
结论:
- 在DS中CG降低与外周化学受体敏感性降低有关,这解释了末端潮PCO2增加和膜低通风.
- 在患有DS和OSAS的儿童中,喉尺寸缩小.
- 结果表明在唐氏综合征中自主神经系统功能障碍.
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