疾病严重程度和并发症对阻塞性睡眠呼吸暂停氧化应激生物标志物的影响
Tuğba Raika Kıran1, Önder Otlu2, Mehmet Erdem2
1Department of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Turkey. raika.kiran@ozal.edu.tr.
Sleep & breathing = Schlaf & Atmung
|July 10, 2023
概括
像缺血变异性白蛋白 (IMA) 和氧化应激标志物 (TOS,TAS) 这样的生物标志物反映了阻塞性睡眠呼吸暂停 (OSA) 的严重程度. 增加的OSA严重程度和并发症与较高的IMA和TOS以及较低的TAS水平相关.
科学领域:
- 生物化学 生物化学
- 睡眠医学 睡眠医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化压力在阻塞性睡眠呼吸暂停 (OSA) 中发挥着作用.
- 缺血变异性白蛋白 (IMA),总氧化剂状态 (TOS) 和总抗氧化剂状态 (TAS) 是氧化应激的潜在生物标志物.
- 在这些生物标志物上,OSA严重程度和并发症的影响需要进一步调查.
研究的目的:
- 研究阻塞性睡眠呼吸暂停 (OSA) 严重程度,并发症和缺血变异性白蛋白 (IMA) 水平,总氧化剂状态 (TOS) 和总抗氧化剂状态 (TAS) 之间的关系.
主要方法:
- 研究包括患有严重的OSA,轻度至中度OSA的患者和健康的对照组,按并发症状况分类.
- 进行了多睡眠扫描,并采集了血液样本进行分析.
- 使用ELISA测量IMA水平,使用商业套件确定TOS和TAS.
主要成果:
- 增加的OSA严重程度和并发症与显著更高的IMA,TOS,呼吸暂停-呼吸暂停指数 (AHI),脱度指数 (T90),胆固醇,LDL,甘油三,AST和CRP相关.
- 相反,TAS,最小脱和平均脱值随着OSA严重程度和并发症的增加而显著下降.
- 在疾病组之间没有观察到性别,吸烟状况,年龄,BMI,HDL,T3,T4,TSH和B12的显著差异.
结论:
- IMA,TOS和TAS水平可以作为与OSA相关的氧化应激的指标.
- 升高的IMA和TOS,以及降低的TAS,与增加的OSA严重程度和并发症的存在有关.
- 在未来对OSA的研究中,应考虑疾病严重程度和并发症状态.
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