转录组分析显示,FABP5是腹脂肪发育的关键参与者,受miR-122-5p准调节
Bin Zhai1, Hongtai Li1, Shuaihao Li1
1College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
BMC genomics
|July 10, 2023
概括
的腹部脂肪发育受到FABP5和miR-122-5p等关键基因的调节. 这项研究揭示了影响古希脂肪沉积和肉质的分子机制.
科学领域:
- 动物科学动物科学
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 腹部脂肪的发育显著影响肉的质量和经济效率.
- 了解脂肪沉积的分子基础对于优化家禽生产至关重要.
研究的目的:
- 确定关键的miRNA-mRNA调节网络,参与古希的腹部脂肪发育.
- 阐明在不同生长阶段的脂肪沉积背后的分子机制.
主要方法:
- 从6,14,22和30周的古希的腹部脂肪组织的转录组测序.
- 时间序列分析和相关性分析以确定差异表达的基因和调节网络.
- 细胞实验验验证miRNA-目标相互作用及其功能影响.
主要成果:
- 1893年分化表达的基因被发现.
- 在早期脂肪发育 (6周) 中,TGF-β,Wnt和PPAR信号通路至关重要.
- 亡信号通路主导后期阶段 (30周),FABP5被确定为关键基因. miR-122-5p直接准FABP5,促进了前脂肪细胞的分化.
结论:
- FABP5及其向的miRNA,miR-122-5p,是腹脂肪发育的关键调节者.
- 这项研究为管理家禽腹部脂肪积累的分子机制提供了新的见解.
- 这些发现有助于理解影响肉质和脂肪沉积的遗传因素.
更多相关视频
08:34Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.1K
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
2.2K
相关概念视频
Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Cholesterol: Significance and Regulation
592
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
592
