确定关键基因和与过敏性鼻炎的过敏特异性免疫疗法相关的病理生理学
Kai Fan1,2, Shican Zhou1,2, Ling Jin1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
BMC immunology
|July 10, 2023
概括
对过敏性鼻炎 (AR) 的过敏特异性免疫疗法 (AIT) 涉及识别关键基因. 这项研究揭示了像PIK3R1这样的新型基因特征,为AIT机制和潜在的治疗点提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 生物信息学是一种生物信息学.
背景情况:
- 过敏特异性免疫疗法 (AIT) 是对过敏性鼻炎 (AR) 的长期治疗方法.
- 了解涉及AIT的分子机制和关键基因对于提高治疗疗效至关重要.
- 这项研究旨在在接受AIT的AR患者中阐明这些机制.
研究的目的:
- 确定与过敏性鼻炎中AIT相关的差异表达基因 (DEGs) 和枢纽基因.
- 探索AIT疗效的潜在治疗点和生物标志物.
- 了解由AIT影响的分子通路.
主要方法:
- 利用基因表达综合 (GEO) 数据集 (GSE37157,GSE29521) 用于差异基因表达分析.
- 进行了基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 路径分析.
- 构建蛋白质-蛋白质相互作用 (PPI) 网络和识别的枢纽基因,包括潜在的miRNA相互作用.
主要成果:
- 在AIT响应者和非响应者之间确定了119个共同上调和33个共同下调的DEG.
- 途径分析突出了自然杀手细胞介导的细胞毒性,T细胞受体信号传递和TNF信号传递途径的参与.
- 关键的枢纽基因,包括CASP3,FOXO3,PIK3R1,PIK3R3,ATF4和POLD3,被确定为AIT反应的可靠预测因素,其中PIK3R1显示出特别重要的意义.
结论:
- 确定了AR中AIT的基础新型基因特征和分子机制.
- 这些发现有助于更好地了解AIT的疗效,并提供治疗反应的潜在生物标志物.
- 突出了PIK3R1作为AIT在过敏性鼻炎中成功的有希望的预测因素.
更多相关视频
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
30.5K
12:08Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
11.3K
相关概念视频
02:06Allergic Reactions
27.8K
Overview
27.8K
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:20Asthma: Pathogenesis and Management
450
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
450
01:10Antibody Structure
60.4K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.4K
01:29Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
351
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
351