2型糖尿病患者24个月的甲状腺功能,血糖控制和糖尿病病:前性观察性研究
Hiroshi Iwakura1, Tomoyuki Takagi2, Hidefumi Inaba3
1The First Department of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan. hiwaku@wakayama-med.ac.jp.
BMC endocrine disorders
|July 10, 2023
概括
甲状腺功能障碍的患病率在2型糖尿病患者和对照人群之间没有差异. 然而,2型糖尿病患者的甲状腺激素比率发生变化,与胰岛素抵抗和血糖控制有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 确立了1型糖尿病和甲状腺功能障碍之间的关联.
- 2型糖尿病和甲状腺功能障碍之间的联系仍在争论中.
- 这项研究研究了2型糖尿病患者的甲状腺功能.
研究的目的:
- 为了确定甲状腺功能障碍是否在2型糖尿病中更为普遍.
- 在2型糖尿病中检查甲状腺自身抗体.
- 探索甲状腺功能,糖尿病控制和功能之间的关系.
主要方法:
- 在200名2型糖尿病患者和225名对照人群中比较甲状腺功能和自身抗体.
- 对2型糖尿病患者进行24个月的随访监测.
- 分析了甲状腺参数,HbA1c,c-和eGFR之间的相关性.
主要成果:
- 2型糖尿病患者的自由三甲状腺素 (fT3) 和自由甲状腺素 (fT3) /自由甲状腺素 (fT4) 比率较低,FT4水平较高.
- 两组之间甲状腺功能障碍或自身抗体患病率没有显著差异.
- fT3/fT4比率与胰岛素抵抗和血糖控制相关 (HbA1c).
- 基底甲状腺功能无法预测24个月内HbA1c或eGFR的变化.
结论:
- 甲状腺功能障碍和自身抗体的患病率在2型糖尿病患者和对照人群之间没有差异.
- 2型糖尿病患者表现出改变的FT3/FT4比率.
- 基本甲状腺功能不是未来糖尿病控制或24个月内功能的预测因素.
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