血糖控制对大动脉狭窄症进展的影响:使用共同数据模型的单中心队列研究
In-Chang Hwang1,2, Seok Kim3, Dachung Boo3
1Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, 82 Gumi-Ro-173-Gil, Seongnam, Gyeonggi, 13620, South Korea. inchang.hwang@gmail.com.
BMC endocrine disorders
|July 10, 2023
概括
控制不良的糖尿病 (DM) 显著加快了大动脉狭窄症 (AS) 的进展. 保持良好的血糖控制 (HbA1c < 7.0%) 对于减缓轻度至中度疾病患者的AS进展至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 医疗信息学 医疗信息学
背景情况:
- 糖尿病是一种已知的风险因素,导致退行性大动脉狭窄症 (AS) 的进展.
- 血糖控制对AS进展率的具体影响仍未得到充分研究.
- 本研究使用基于电子健康记录的共同数据模型 (CDM) 来研究这种关系.
研究的目的:
- 评估血糖控制与AS进展速度之间的关联.
- 为了确定血糖控制不良是否加速AS在轻度至中度AS患者的进展.
主要方法:
- 从第三级医院CDM中对轻度或中度AS患者的回顾性分析.
- 患者分为没有DM,DM控制良好 (HbA1c <7.0%) 和DM控制不良 (HbA1c ≥7.0%) 的患者.
- 动脉最大速度 (Vpeak) 的年度变化量化的AS进展率.
主要成果:
- 较高的平均HbA1c水平与AS进展率正相关 (β=2.620,p=0.007).
- 1%的HbA1c增加与加速AS进展的27%更高风险相关 (aOR=1.267).
- 控制不良的DM (HbA1c ≥7.0%) 显著增加了加速AS进展的几率 (aOR=1.524,p=0.043).
结论:
- 糖尿病的存在和血糖控制的程度都与AS进展的加速显著相关.
- 有效的血糖管理对于减轻AS在轻度至中度疾病患者的进展至关重要.
- 研究结果强调了糖尿病管理对心血管健康的重要性,特别是对于AS患者.
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