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Updated: Jul 24, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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关于瘤免疫微环境 (TIME) 的出版物的全球生产力和研究趋势:一项文献计量研究

Yao-Ge Liu1, Shi-Tao Jiang1, Lei Zhang1

  • 1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.

European journal of medical research
|July 10, 2023
PubMed
概括

这项对瘤免疫微环境 (TIME) 研究的文献分析显示,出版物数量显著增加. 关键领域包括癌症免疫疗法和免疫检查点,未来的前沿是精确免疫疗法.

关键词:
图书统计学 图书统计学城市空间是城市空间.边界的边界 边界的边界瘤免疫微环境 (时间)在VOSviewer中使用VOSviewer.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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