有证据表明,与75岁以上的成年人身体虚弱相关的性别特异性肌肉内变化
Jelle C B C de Jong1,2, Lars Verschuren3, Martien P M Caspers3
1Human and Animal Physiology, Wageningen University, P.O. Box 338, 6700AH, Wageningen, The Netherlands.
Biology of sex differences
|July 10, 2023
概括
老年人的身体软弱表现出明显的性别特异性肌肉变化. 女性表现出炎症,而男性显示快速肌肉纤维和PRKN表达减少,影响脆弱性干预.
科学领域:
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
- 分子生物学分子生物学
背景情况:
- 身体虚弱是脆弱的关键组成部分,在老年人中普遍存在.
- 女性表现出更高的患病率和早期发病的脆弱性相关的身体软弱.
- 脆弱性发展中的性别差异未得到充分研究,因此需要对肌肉内变化的研究.
研究的目的:
- 为了研究性别特异性的肌肉内变化,区分适合和弱弱的老年人.
- 识别性别之间的肌肉组织中的分子和组织学差异,与身体虚弱相关.
- 评估与肌肉脆弱相关的肌肉变化是否与衰老过程不同.
主要方法:
- 研究包括男性 (n=28) 和女性 (n=26) 的老年人 (75岁以上).
- 根据身体表现标准,参与者被分为最适合和最弱的组.
- 从vastus lateralis肌肉活检分析了转录组和组织学,并按性别对对比.
主要成果:
- 较弱的女性表现出更高的炎症途径表达和免疫细胞透 (NOX2,VCAM1).
- 较弱的雄性表现出较小的2型肌纤维直径和较低的PRKN表达.
- 与衰弱相关的肌肉转录组变化与衰老不同,表明不同的病理生理学.
结论:
- 与身体虚弱相关的肌肉变化是性别特异的.
- 在脆弱性研究和干预措施的开发中,必须考虑性别差异.
- 了解这些性别特异性机制可以为针对脆弱性的药物和治疗策略提供信息.
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