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在接受肝,胰腺,胆道癌手术的患者中,术后的氧化还原变化

Jia L Stevens^1,2, Helen T McKenna³, Helder Filipe⁴

¹Division of Surgery and Interventional Science, Royal Free Hospital, University College London, London, NW3 2QG, UK. Jia.stevens@ucl.ac.uk.

Perioperative medicine (London, England)

|July 10, 2023

概括

大型手术增加了氧化和化应激,以及身体的减肥能力. 较低的基线酸盐水平预测了更高的术后发病率,表明其在手术结果中的作用.

科学领域:

生物化学生物化学
生理学生理学生理学
手术科学手术科学

背景情况:

组织损伤和手术压力引发炎症和反应性氧/物种的形成.
氧化和/或化应激 (ONS) 途径被激活,但术后数据有限.
这项研究探讨了大手术后的ONS和氧化还原状态变化.

研究的目的:

研究大手术对氧化和化应激的影响.
评估在外科手术期间系统性氧化还原状态的变化.
探索ONS标志物与术后发病率之间的关联.

主要方法:

来自56名患者的血液样本在基线,手术结束和手术后的第一天被分析.
测量的标记物包括脂质氧化 (TBARS,4-HNE,8-异质),降解能力 (TFTs,FRAP),氧化 (NO) 代谢 (cGMP,亚酸盐,酸盐,RxNO) 和炎症性细胞因子 (IL-6,TNF-α).
术后发病率使用克拉维恩 - 丁多系统进行分类.

主要成果:

在手术期间,氧化应激 (TBARS) 和化应激 (总化物种) 的增加,以及降低能力的增加.
亚酸盐,酸盐和cGMP水平从基线下降到手术后的第一天.
较低的基线酸盐和较大的手术内增加的TBARS与严重的术后发病率有关. 酸盐和cGMP显著下降也与较差的结果有关.

结论:

大型手术提高了手术期间的氧化和化应激,加上减少能力的增加.
基线酸盐水平与术后发病率相反相关.
改变氧化应激和氧化代谢是不良外科手术结果的关键指标.

关键词:

疾病发病率疾病发病率亚酸性压力是一种压力.氧化应激是一种氧化应激.经期操作性经期操作性有反应性氧物种的反应性氧物种.外科手术手术手术

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