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皮肤黑色素瘤中的PRAME表达与疾病特异性存活率无关

Ourania Parra^1,2, Weijie Ma^1,2, Zhongze Li³

¹Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Journal of cutaneous pathology

|July 11, 2023

概括

基-67是皮肤黑色素瘤的显著预后标志物,预测生存率. 虽然在黑色素瘤中偏偏表达抗原 (PRAME) 有助于区分瘤和黑色素瘤,但它不能独立预测患者的存活率.

科学领域:

在瘤学瘤学.
皮肤病理学皮肤病理学
生物标志物研究生物标志物研究

背景情况:

免疫组织化学生物标志物为皮肤黑色素瘤提供预后见解.
基-67的预后价值是有争议的;在黑色素瘤中偏偏表达抗原 (PRAME) 是黑色素瘤分化的新标志物,但其预后作用尚未研究.

研究的目的:

评估在肌肤黑色素瘤中作为预后标志物的偏偏表达抗原 (PRAME).
为了比较PRAME与Ki-67.7的预后值.

主要方法:

在165种黑色细胞病变中对PRAME和Ki-67进行免疫组合化学分析 (92种原发性黑色素瘤,19种转移性黑色素瘤,54种瘤).
通过核阳性百分比来评分PRAME,通过核扩散指数来评分Ki-67.
与临床病理特征和疾病特异性生存率的相关性.

主要成果:

无论是PRAME还是Ki-67,在黑色素瘤和瘤中都显著升高.
基-67指数在转移性黑色素瘤中较高,与,布雷斯洛深度和线性速率相关.
增加的Ki-67预测了原发性黑色素瘤的生存率更差;PRAME没有显示独立的预后意义.

结论:

Ki-67 是皮肤黑色素瘤的独立预后标志物.
PRAME与Ki-67和线粒速率相关,但不是一个独立的预后标志物.
PRAME和Ki-67都是有价值的辅助工具,用于区分良性瘤和恶性黑色素瘤.

关键词:

在 Ki-67 机器人普拉梅姆是什么意思?良性神经脉 (benign nevus) 是一种良性的神经脉.皮肤性恶性黑色素瘤预后预后预后幸存率幸存率生存率组织微阵列.

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